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3. Acta Pharmaceutica - Sciendo
Acta Pharmaceutica (AP) is an international, scientific, multidisciplinary journal, devoted to the pharmaceutical and allied sciences, which contains ...
Acta Pharmaceutica (AP) is an international, scientific, multidisciplinary journal, devoted to the pharmaceutical and allied sciences, which contains articles predominantly on core biomedical and...
4. New Donors | Octapharma Plasma
Find out everything you need to know about plasma donor eligibility, first time plasma donation requirements and new donor bonus payment incentives.
5. [PDF] Quantification of Cyclobenzaprine in Human Plasma by LC/MS/MS and ...
30 okt 2020 · “Quantification of Cyclobenzaprine in Human Plasma by LC/MS/MS and its Pharmaco*kinetics Application”. Acta Scientific. Pharmaceutical Sciences ...
6. [PDF] Determination of donepezil hydrochloride in human plasma ...
Therefore, plasma drug concentration can be a useful tool to predict the clinical out- come of donepezil in the treatment of Alzheimer's disease. 403. Acta ...
7. Academisch Centrum Tandheelkunde Amsterdam
Bevat niet: pharma plasma
Het Academisch Centrum Tandheelkunde Amsterdam (ACTA) leidt tandartsen op om het gebit van mensen te verzorgen en doet onderzoek om die zorg te verbeteren.
8. Acta Pharmaceutica Nordica | EVISA's Journals Database
What's new on EVISA's web site ? Iodine Speciation Analysis in Drinking Water Using Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry.
European Virtual Institute for Speciation Analysis ( EVISA )
9. [PDF] Determination of Donepezil in Human Plasma and its Clinical Applications
30 apr 2021 · “Determination of Donepezil in Human Plasma and its Clinical Applications". Acta Scientific Pharmaceutical Sciences 5.5. (2021): 67-75. Page ...
10. Acta Naturae
Acta Naturae is also a periodical for those who are curious in various aspects of biotechnological business, innovations in pharmaceutical areas, intellectual ...
Acta Naturae
11. [PDF] ACTA PHARMACEUTICA SCIENCIA - Medipol Üniversitesi
... plasma (A), fexofenadine pure drug (B), cetir. Figure 7. Representative chromatograms of blank plasma (A), fexofenadine pure drug (B), cetirizine (C) and ...
12. Why 90% of clinical drug development fails and how to improve it? - PMC
Acta Pharm Sin B. 2022 Jul; 12(7): 3049–3062 ... This hypothesis believes that only free unbound drug from plasma (not plasma ... drug–drug interactions in treating ...
Ninety percent of clinical drug development fails despite implementation of many successful strategies, which raised the question whether certain aspects in target validation and drug optimization are overlooked? Current drug optimization overly emphasizes ...
13. [PDF] Bioequivalence Study of Two Different Formulations of Ceftiofur Following ...
Plasma samples were transferred frozen to ARGEFAR (Research and. Application Center of Drug Development and Pharmaco*kinetics)/. Ege University for analysis.
14. Acta Pharm Nord journal articles from PubMed - Unbound Medicine
PubMed Journal articles for Acta Pharm Nord were found in PRIME PubMed ... All esters were readily hydrolyzed enzymatically by human plasma. ... The influence of ...
PubMed Journal articles for Acta Pharm Nord were found in PRIME PubMed. Download Prime PubMed App to iPhone, iPad, or Android
15. ACTA Pharmaceutica Sciencia
Bevat niet: plasma | Resultaten tonen met:plasma
As of 01.10.2023 , the print version has been stopped and the journal continues as an electronic version.
16. Plasma-derived medicines: access and usage issues - PMC - NCBI
Unlike the situation for most pharmaceuticals, the costliest component of the manufacture of plasma protein therapies is the raw material, plasma. In well- ...
As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsem*nt of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice
17. A novel HPLC method for selexipag in human plasma and application to a ...
23 nov 2023 · LOD is found to be 3.3 ng mL−1 for drug. The method was applied to the analysis of SLP in human plasma with good recovery as 97.83%. Validation ...
Abstract A novel simple and cost effective HPLC technique was presented for the quantification of selexipag (SLP) in human plasma sample and the technique's applicability to a pharmaco*kinetic investigation. Chromatographic separation was achieved with C18 (5 µm × 4.6 mm × 150 mm) column, at 30 °C with isocratic elution, mobile phase composed of solution A (acetonitrile), and solution B (0.5% formic acid) (65:35 v/v) at flow rate 1.2 mL min−1. The linearity range is 10–150 ng mL−1. As sample preparation step human plasma was precipitated with acetonitrile and the detection was provided at 300 nm. The retention time is 8.20 ± 0.02 min. LOD is found to be 3.3 ng mL−1 for drug. The method was applied to the analysis of SLP in human plasma with good recovery as 97.83%. Validation of the studied methods was carried out according to EMA guideline. The new method applied on a prototype pharmaco*kinetic study by administration of 800 μg SLP to a healthy volunteer and parameters like AUC0–24, AUC0–∞, Cmax, tmax, and t1/2 were assessed.
18. Plasma polymerized nanoparticles effectively deliver dual siRNA and ...
30 jul 2020 · Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: Core–shell nanoparticle carrier and drug release response. Acta ...
Multifunctional nanocarriers (MNCs) promise to improve therapeutic outcomes by combining multiple classes of molecules into a single nanostructure, enhancing active targeting of therapeutic agents and facilitating new combination therapies. However, nanocarrier platforms currently approved for clinical use can still only carry a single therapeutic agent. The complexity and escalating costs associated with the synthesis of more complex MNCs have been major technological roadblocks in the pathway for clinical translation. Here, we show that plasma polymerized nanoparticles (PPNs), synthesised in reactive gas discharges, can bind and effectively deliver multiple therapeutic cargo in a facile and cost-effective process compatible with up scaled commercial production. Delivery of siRNA against vascular endothelial growth factor (siVEGF) at extremely low concentrations (0.04 nM), significantly reduced VEGF expression in hard-to-transfect cells when compared with commercial platforms carrying higher siRNA doses (6.25 nM). PPNs carrying a combination of siVEGF and standard of care Pacl*taxel (PPN-Dual) at reduced doses (< 100 µg/kg) synergistically modulated the microenvironment of orthotopic breast tumors in mice, and significantly reduced tumor growth. We propose PPNs as a new nanomaterial for delivery of therapeutics, which can be easily functionalised in any laboratory setting without the need for additional wet-chemistry and purification steps.
19. [PDF] ACTA PHARMACEUTICA SCIENCIA - Medipol Üniversitesi
the drug concentration (1/X2). RESULTS AND DISCUSSION. It was reported earlier that abiraterone is unstable in blood/plasma in the ab- sence of fluoride 14, 15.
20. Biomedical and Pharmaceutical Applications of Inductively Coupled ...
Since 1980, inductively coupled plasma-mass spectrometry (ICP-MS) has emerged as a new and powerful technique for elemental and isotopic analysis. It provides a ...
Medical science is a field of study that is relevant to all people, but the development of pharmaceutical, biomedical and life science is of particular importance. In these fields, further studies are being established to determine with incredible accuracy the quantities and concentration of inorganic elements and organic compounds, such as nucleotides, sulphur and phosphorous containing peptides and proteins, to be used in all kinds of drugs. Since 1980, inductively coupled plasma-mass spectrometry (ICP-MS) has emerged as a new and powerful technique for elemental and isotopic analysis. It provides a means for the analysis of an extremely wide range of elements and the co-analysis of most elements in the periodic table. It can also be used for qualitative, quantitative and semiquantitative analysis and for the measurement of isotopic ratios through mass-to-charge ratios. In recent years, ICP-MS has emerged as the best technique for the quantification of inorganic impurities in pharmaceutical and biomedical applications. This chapter focuses on introducing the applications of ICP-MS in the pharmaceutical and biomedical fields. Some problems facing ICP-MS are also presented at the end of this chapter.
21. Penetration of moxifloxacin into rat mandibular bone and soft tissue
1 jan 2009 · Uwe Thuss Bayer HealthCare AG, Pharma Research Center, Preclinical Pharmaco*kinetics, Wuppertal, Germany ... masseter:plasma = 2.64 and mandibles: ...
Objective. Based on its in vitro activity and spectrum of activity, the new 8-methoxyquinolone antibiotic moxifloxacin (MXF) seems suited for the antibiotic therapy of odontogenic infections. Penetration into the relevant tissue is another prerequisite for clinical efficacy. For this reason, the levels of MXF in plasma, soft tissue, and mandibular bone were determined in an animal model with Wistar rats. Material and methods. Samples of 49 rats were analyzed. Tissue samples were hom*ogenized and proteins were precipitated. The pharmaco*kinetic evaluation was conducted based on non-compartmental analysis. Results. The concentration-time courses of tissues show a more plateau-shaped curve compared to plasma. Calculated AUC (area under the curve) ratios tissue:plasma were M. masseter:plasma = 2.64 and mandibles:plasma = 1.13. Conclusions. Administration of antibiotics is considered an important part of therapy during and/or after surgical procedures in the maxillofacial area. Because of the good penetration into bone and muscle tissues demonstrated in Wistar rats, MXF might be an option for clinical application in this indication.
22. [PDF] acta poloniae - pharmaceutica - Polskie Towarzystwo Farmaceutyczne
Acta Poloniae Pharmaceutica с Drug Research, Vol. ... The maximum drug plasma concentra- tion (Cmax) ... 400 mg film-coated tablets manufactured by Novartis Pharma ...
23. Influence d'acides gras saturés et non saturés sur la pression de filtration ...
4 mrt 2009 · Thus, with the technique of filtration pressure of platelet-rich plasma, one finds an increase in filtration pressure as a function of the ...
Abstract. The influence of the salts of saturated and non-saturated fatty acids from C8 to C22 on the aggregation of human platelets is compared within the framework of 2 different techniques: the test of filtration pressure, in correlation with the classical photometric test of aggregation. Thus, with the technique of filtration pressure of platelet-rich plasma, one finds an increase in filtration pressure as a function of the number of carbon molecules in the chain used. The presence of a double bond generally results in a decrease in filtration pressure. In the classical photometric test the fatty acids induce a progressive and irreversible deviation curve, demonstrating both the aggregation of platelets and the probable bonding of the fatty acids with plasmatic proteins. The presence and intensity of platelet aggregation are related to the molecular weight of the chain of fatty acids under consideration and inhibited by the presence of double bonds. From the similarity of the results obtained with the 2 techniques, one might surmise that the filtration pressure test is a new approach to platelet aggregation.
